Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

IA-Alkyne

SKU: orb1308213

Description

IA-Alkyne is a TRPC channel agonist used to create isotopically tagged probes for quantitative cysteine-reactivity profiling. Its applications extend to studying respiratory infections in both in vitro and in vivo experimental models, facilitating research in chemical proteomics and host-pathogen interactions.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number930800-38-7
MW265.09
Purity≥98% (May vary between batches)
FormulaC8H12INO
SMILESC(NC(CI)=O)CCCC#C
TargetTRP/TRPV Channel
SolubilityDMSO:55 mg/mL (207.48 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.54 mM)

Bioactivity

In Vitro
IA-alkyne (2.5-10 μM; 1 hour) reacts with cysteines. In-gel fluorescence imaging indicates strong fluorescent intensity of IA-alkyne. Labeled proteome samples are conjugated with a fluorescent rhodamine-azide tag via CuAAC and analyzed by SDS-PAGE. Soluble fractions of HeLa cell lysates (2.0 mg/ml) are treated with IA-alkyne .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TRP Channel, TRPC, TRPChannel, TRPV Channel, TRPVChannel, Transient receptor potential channels, emphysema, Fluorescence, IA Alkyne, IAAlkyne, IA-Alkyne, gel, Inhibitor, imaging, Iodoacetamide-alkyne, inhibit, N-Hex-5-ynyl-2-iodo-acetamide, obstructive, asthma, bronchiectasis, cysteine, cystic fibrosis, chronic, chronic bronchitis

Similar Products

  • IA-alkyne(Pr) [orb2815390]

    50 mg, 10 mg
  • IA-Alkyne [orb1941122]

    >98% (HPLC)

    930800-38-7

    265.09

    C8H12INO

    10 mg, 25 mg, 50 mg, 100 mg, 2 mg, 500 mg, 1 g, 5 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 170.00
5 mg
$ 170.00
10 mg
$ 240.00
25 mg
$ 320.00
50 mg
$ 390.00
100 mg
$ 520.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry