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IBR2

SKU: orb1309559

Description

IBR2 is a specific RAD51 inhibitor that disrupts RAD51 multimerization and promotes its proteasomal degradation, thereby suppressing homologous recombination repair. This compound inhibits cancer cell proliferation and induces apoptosis, making it a valuable tool for studying DNA repair mechanisms in cancer research, both in vitro and in vivo.

Research Area

Cell Biology, Molecular Biology

Images & Validation

Key Properties

CAS Number313526-24-8
MW400.49
Purity99.50% (May vary between batches)
FormulaC24H20N2O2S
SMILESO=S(=O)(Cc1ccccc1)N1C=Cc2ccccc2C1c1c[nH]c2ccccc12
TargetDNA/RNA Synthesis,Apoptosis
SolubilityDMSO:100 mg/mL (249.69 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.99 mM)

Bioactivity

Target IC50
RAD51:14.8 µM(triple-negative human breast cancer cell line MBA-MD-468)
In Vitro
IBR2 can inhibit the growth of triple-negative human breast cancer cell line MBA-MD-468 with IC50 of 14.8 μM. IBR2 shows interesting RAD51 inhibition activities. RAD51 is rapidly degraded in IBR2-treated cancer cells, and the homologous recombination repair is impaired, subsequently leading to cell death. The IC50 values of the original IBR2 are in the range of 12-20 μM for most tested cancer cell lines.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apoptosis, DNA Synthesis, DNASynthesis, Inhibitor, IBR 2, IBR2, IBR-2, inhibit, Isoquinoline, RAD51, RNA Synthesis, RNASynthesis
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Key Properties

No computed properties available.

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IBR2 (orb1309559)

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Available Sizes

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1 mg
¥ 910.00
1 ml x 10 mM (in DMSO)
¥ 1,430.00
5 mg
¥ 1,430.00
10 mg
¥ 2,080.00
25 mg
¥ 3,120.00
50 mg
¥ 4,160.00
100 mg
¥ 5,460.00
200 mg
¥ 7,800.00
DispatchUsually dispatched within 3-5 working days
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