ICI 199,441 hydrochloride

SKU: orb1704478

Description

ICI 199,441 hydrochloride is a selective and high-affinity κ-opioid receptor (KOR) agonist. It is widely used in neuroscience research to study KOR-mediated analgesia, dysphoria, and diuresis in both in vitro binding assays and in vivo animal models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	115199-84-3
MW	427.8
Purity	99.57% (May vary between batches)
Formula	C₂₁H₂₅Cl₃N₂O
SMILES	Cl.CN([C@H](CN1CCCC1)c1ccccc1)C(=O)Cc1ccc(Cl)c(Cl)c1
Target	Opioid Receptor
Solubility	Ethanol:50 mM;DMSO:225 mg/mL (525.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.69 mM)

Bioactivity

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In Vivo	Administration of ICI 199,441 in a dose of 0.1 mg/kg 15 min before ischemia produced a potent antiarrhythmic effect in Wistar rats.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ICI 199,441 hydrochloride, ICI 199,441 Hydrochloride, OpioidReceptor, Opioid Receptor, κ-opioid receptor

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Compound Identifiers

PubChem CID

3082717 ↗

Key Properties

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No computed properties available.

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