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IDH889

SKU: orb1308208

Description

IDH889 is a brain-penetrant, allosteric inhibitor that selectively targets mutant IDH1 R132H/C over the wild-type enzyme. This selectivity makes it a valuable research tool for investigating mutant IDH1-driven pathologies, such as glioma, in both cellular and animal models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1429179-07-6
MW436.48
Purity≥98% (May vary between batches)
FormulaC23H25FN6O2
SMILESCC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ncc(cn2)-c2ccc(F)c(C)c2)n1
TargetDehydrogenase,Isocitrate Dehydrogenase (IDH)
SolubilityDMSO:60 mg/mL (137.46 mM);10% DMSO+90% Corn Oil:5 mg/mL (11.46 mM)

Bioactivity

Target IC50
IDH1 (R132C):0.072 μM|IDH1 (R132H):0.02 μM|IDH1 (WT):1.38 μM
In Vitro
IDH889 displays effective cellular inhibition of R-2-hydroxyglutarate (2-HG) production (IC50: 0.014 μM).

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, Isocitrate Dehydrogenase (IDH), IDH1wt, IDH889, IDH-889, IDH1-R132H, IDH1R132H, IDH 889, IDH1R132C, IDH1-R132C
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

IDH889 (orb1308208)

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% Tween 80 +
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Available Sizes

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1 mg
¥ 1,950.00
5 mg
¥ 3,770.00
1 ml x 10 mM (in DMSO)
¥ 4,160.00
DispatchUsually dispatched within 3-5 working days
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