IFNAR-1 mAb (MAR1-5A3), InVivoPure+

SKU: orb3127238

Description

Anti-IFNAR-1 (clone MAR1-5A3) is a mouse monoclonal antibody targeting the extracellular domain of the murine interferon alpha/beta receptor subunit 1 (IFNAR-1). It is widely used to block type I interferon signaling in both in vitro and in vivo models. The antibody was developed by immunizing mice via hydrodynamic transfection, a method that induces strong immune responses against membrane proteins. MAR1-5A3 has been shown to effectively inhibit IFN-α/β signaling, making it a valuable tool in studies of viral pathogenesis, autoimmune diseases, and tumor immunology . It is used in neutralization assays, flow cytometry, and functional studies to dissect the role of type I IFNs in immune responses.

Images & Validation

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Item 1 of 2

Tested Applications	ELISA, FC, WB
Reactivity	Mouse
Application Notes	Recomended Isotype: Mouse IgG1ĸ Isotype Control, Recomended Isotype Catalog: orb2568795

Key Properties

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Antibody Type	Primary Antibody
Host	Mouse
Clonality	Monoclonal
Isotype	Mouse IgG1
Clone No.	MAR1-5A3
Immunogen	Extracellular domain of murine IFNAR1
Target	IFNAR-1, MAR1-5A3, CD118
Purity	≥ 95 % (CGE, reducing conditions) ≤ 5 % aggregates (analytical SEC) Endotoxin level ≤ 1 EU/mg
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Form/Appearance	Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
Concentration	≥ 1 mg/ mL
Disclaimer	For research use only

Alternative Names

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IFNAR1, CD118, Ifar, Ifnar, Ifcrc, INF-a receptor, and Interferon-α/β receptor α chain precursor, IFN-alpha/beta Receptor 1, Type I interferon receptor 1, and Cytokine receptor class-II member 1.

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Quick Database Links

Gene Symbol

IFNAR-1, MAR1-5A3, CD118

UniProt

P33896

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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Flow Cytometry

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ELISA

Enzyme-linked Immunosorbent Assay (EIA)

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