Imipramine hydrochloride

SKU: orb1299365

Description

Imipramine HCl is a tricyclic antidepressant that potently inhibits serotonin and norepinephrine reuptake. It is also reported to suppress extracellular vesicle release by inhibiting acid sphingomyelinase translocation, making it a useful research tool for studying neurotransmission and vesicular trafficking in cellular and animal models.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	113-52-0
MW	316.87
Purity	99.65% (May vary between batches)
Formula	C₁₉H₂₅ClN₂
SMILES	CN(C)CCCN1c2ccccc2CCc2ccccc21.Cl
Target	Autophagy,Apoptosis,Serotonin Transporter
Solubility	DMSO:100 mg/mL (315.59 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.62 mM);H2O:100 mg/mL (315.59 mM)

Bioactivity

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Target IC50	5-HT:32 nM (IC50)

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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5-HTT, Imipramine, Imipramine (hydrochloride), Imipramine HCl, Imipramine hydrochloride, Imipramine Hydrochloride, inhibit, Inhibitor, Melipramine, G 22355, G22355, G-22355, SERT, Serotonin Transporter, SerotoninTransporter, serotonin, Tofranil, SLC6A4

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Compound Identifiers

PubChem CID

8228 ↗

Key Properties

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No computed properties available.

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