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Imipramine

SKU: orb1705856

Description

Imipramine is an orally active Fascin1 inhibitor with antidepressant properties that also exhibits antitumor activity. It functions as a potent serotonin transporter blocker (IC50: 32 nM) and induces apoptosis and autophagy in glioma cells. Its neuroprotective and immunomodulatory effects, including inhibition of tumor cell invasion, make it a valuable research tool for studying cancers like glioblastoma and breast cancer, as well as neurological disorders.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number50-49-7
MW280.41
Purity99.40% (May vary between batches)
FormulaC19H24N2
SMILESC=1C=CC2=C(C1)N(C=3C=CC=CC3CC2)CCCN(C)C
TargetAutophagy,Apoptosis,Serotonin Transporter
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (17.83 mM);DMSO:100 mg/mL (356.62 mM)

Bioactivity

Target IC50
placental serotonin transporter (human):32 nM
In Vivo
In male C57BL/6 mice (6-8 weeks old) exposed to repeated social defeat (RSD) and home cage control (HCC), Imipramine (20 mg/kg or 15 mg/kg; administered intraperitoneally or orally, daily for 24 days) reversed RSD-induced social avoidance behavior, significantly increasing interaction time, and significantly decreased stress-induced mRNA levels for IL-6 in brain microglia.
In Vitro
In DLD-1, HCT-116, and SW-480 cell lines, Imipramine (0.5-300 μM; 3 days) inhibited cell viability, with HCT-116 being more sensitive to it compared to DLD-1 and SW-480.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

HSDB 3100, HSDB3100, HSDB-3100, Melipramine, fascin 1, Imipramine, Dimipressin, Apoptosis

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Key Properties

No computed properties available.

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Imipramine (orb1705856)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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5 mg
¥ 1,300.00
10 mg
¥ 1,690.00
25 mg
¥ 2,860.00
50 mg
¥ 4,030.00
100 mg
¥ 6,110.00
500 mg
¥ 13,130.00
DispatchUsually dispatched within 6-8 weeks
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