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Inarigivir ammonium

SKU: orb1298048

Description

Inarigivir ammonium (SB-9200) is a dinucleotide RIG-I agonist that activates innate immunity to combat hepatitis B virus. It has demonstrated antiviral efficacy in reducing HBV DNA in transgenic mouse models and has been investigated in vitro for its immunostimulatory mechanisms against viral infections.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number2172788-92-8
MW604.53
Purity99.13% (May vary between batches)
FormulaC20H29N8O10PS
SMILESNC1=C(N=CN2[C@@H]3O[C@H](COP(O[C@H]4[C@@H](OC)[C@H](N5C=CC(NC5=O)=O)O[C@@H]4CO)(S)=O)[C@@H](O)C3)C2=NC=N1.N
TargetHBV
SolubilityDMSO:98 mg/mL (162.11 mM)

Bioactivity

In Vivo
Administration of 100 mg/kg/day Inarigivir (ip) significantly reduces viral DNA in the liver and shows anti-HBV activity while serum HBV DNA is not reduced. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values.
In Vitro
Inarigivir exhibits activity against HBV (hepatitis B virus) variants, including those resistant to all approved nucleo(s)tide analogues for chronic hepatitis B treatment.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ORI 9020, ORI9020, ORI-9020, ORI-9020 ammonium, SB 9000, SB9000, SB-9000, SB-9200 ammonium, RIG-I, antiviral, Hepatitis B virus, HCV, HBV, Inhibitor, Huh7, inhibit, Inarigivir, Inarigivir ammonium
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 mg
$ 100.00
5 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 210.00
10 mg
$ 240.00
25 mg
$ 420.00
50 mg
$ 660.00
100 mg
$ 1,040.00
200 mg
$ 1,370.00
DispatchUsually dispatched within 3-5 working days
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