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Inarigivir soproxil

SKU: orb1308199

Description

Inarigivir soproxil (SB9200) is an innate immunity agonist with antiviral activity. It demonstrates efficacy against resistant hepatitis C virus variants, showing EC50 values of 2.2 and 1.0 μM in genotype 1 replicon assays. Its research applications include studying host-directed antiviral mechanisms in both cellular and animal models of viral infection.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number942123-43-5
MW703.62
Purity98.35% (May vary between batches)
FormulaC25H34N7O13PS
SMILESO(C)[C@H]1[C@@H](O[C@H](CO)[C@H]1OP(OC[C@H]2O[C@H](C[C@@H]2O)N3C=4C(N=C3)=C(N)N=CN4)(SCOC(OC(C)C)=O)=O)N5C(=O)NC(=O)C=C5
TargetHBV,HCV Protease
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (5.68 mM);DMSO:102 mg/mL (144.96 mM)

Bioactivity

Target IC50
HCV 1a/1b:(EC50)2.2/1.0 μM
In Vitro
Inarigivir soproxil is shown to inhibit HCV replication and the range of inhibition is comparable between genotypes 1a and 1b. Inarigivir soproxil is an oral modulator of innate immunity that is believed to act via the activation of the RIG-I and NOD2 pathways. Inarigivir soproxil demonstrates pan-genotypic antiviral activity against HCV. Inarigivir soproxil is active against DAA-resistant HCV variants. SB 9200 has broad-spectrum antiviral activity against RNA viruses including hepatitis C virus (HCV), norovirus, respiratory syncytial virus and influenza and has demonstrated activity against hepatitis B virus (HBV).

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SB9200, SB-9200, SB 9200, antiviral activity against, HCVProtease, HCV Protease, HCV replicon, HCV 1a/1b, HCV, HBV, Hepatitis C virus, Hepatitis B virus, innate immunity, GS 9992, GS9992, GS-9992, inhibit, Inarigivir soproxil, Inhibitor

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 210.00
5 mg
$ 370.00
10 mg
$ 540.00
1 ml x 10 mM (in DMSO)
$ 560.00
25 mg
$ 890.00
50 mg
$ 1,200.00
100 mg
$ 1,610.00
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