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Indibulin

SKU: orb1308196

Description

Indibulin

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number204205-90-3
MW389.83
Purity99.83%
FormulaC22H16ClN3O2
SMILESClc1ccc(Cn2cc(C(=O)C(=O)Nc3ccncc3)c3ccccc23)cc1
TargetChk,Apoptosis,Microtubule Associated
Solubility10% DMSO+90% Corn Oil:2.5 mg/mL (6.41 mM);DMSO:50 mg/mL (128.26 mM)

Bioactivity

In Vitro
Indibulin, a synthetic inhibitor of tubulin assembly, has shown promising anticancer activity. Using time-lapse confocal microscopy, indibulin dampens the dynamic instability of individual microtubules in live breast cancer cells. Indibulin treatment also perturbed the localization of end-binding proteins at the growing microtubule ends in MCF-7 cells. Indibulin reduced inter-kinetochoric tension, produced aberrant spindles, activated mitotic checkpoint proteins Mad2 and BubR1, and induced mitotic arrest in MCF-7 cells. Indibulin-treated MCF-7 cells underwent apoptosis-mediated cell death. Further, the combination of indibulin with an anticancer drug vinblastine was found to exert synergistic cytotoxic effects on MCF-7 cells. Interestingly, indibulin displayed a stronger effect on the undifferentiated neuroblastoma (SH-SY5Y) cells than the differentiated neuronal cells. Unlike indibulin, vinblastine and colchicine produced similar depolymerizing effects on microtubules in both differentiated and undifferentiated SH-SY5Y cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

D 24851, D24851, D-24851, Apoptosis, Inhibitor, Indibulin, inhibit, Microtubule/Tubulin, MicrotubuleAssociated, Microtubule Associated, ZIO 301, ZIO301, ZIO-301, Tubulin

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  • Indibulin [orb1219290]

    >98% (HPLC)

    204205-90-3

    389.83

    C22H16ClN3O2

    500 mg, 2 mg, 100 mg, 1 g, 200 mg, 25 mg, 5 mg, 10 mg, 50 mg
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Key Properties

No computed properties available.

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Indibulin (orb1308196)

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% DMSO +
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% Tween 80 +
%

Available Sizes

Select a size below

1 ml x 10 mM (in DMSO)
¥ 1,040.00
5 mg
¥ 1,040.00
10 mg
¥ 1,300.00
25 mg
¥ 2,080.00
50 mg
¥ 2,990.00
100 mg
¥ 4,420.00
200 mg
¥ 6,890.00
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