Inebilizumab Antibody

SKU: orb1980730

Description

Inebilizumab is a humanized monoclonal antibody targeting CD19, designed to deplete B cells via enhanced antibody-dependent cellular cytotoxicity. It is utilized in research on autoimmune conditions like neuromyelitis optica spectrum disorder and multiple sclerosis, with applications in both in vitro B cell assays and in vivo disease models.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	1299440-37-1
MW	146.60 kDa
Purity	99.1% (SDS-PAGE); 96.2% (SEC-HPLC)
Target	Immunology/Inflammation related,ADC Antibody

Bioactivity

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In Vivo

In vivo, Inebilizumab (MEDI-551) (i.v.; once; 0-10 mg/kg) depletes B cells from blood and spleen by mouse macrophages, and it induces phagocytosis of murine B cells ex vivo.

In Vitro

Derived from the mouse anti-human mAb HB12b, Inebilizumab had already shown impressive activity in depleting B cells in transgenic mice carrying the human CD19 gene (hCD19 Tg). Inebilizumab potently depletes CD19-expressing B cells, including primary human B cells, B cell lines derived from multiple tumor types, and neoplastic B cells. Inebilizumab demonstrates equal or better activity than Rituximab in depleting human primary B cells in autologous ADCC assays and shows potent ADCC activity against human in vitro-differentiated and primary plasma cells.

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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VIB 0551, VIB0551, VIB-0551, Inebilizumab, MT0551, MT-0551, MT 0551, MEDI551, MEDI-551, MEDI 551, 16C4-aFuc, ADC Antibody, ADCAntibody

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Gene Symbol

Immunology/Inflammation related,ADC Antibody

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