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Inosine

SKU: orb1310617

Description

Inosine, an endogenous purine nucleoside metabolite of adenosine, acts as an agonist at adenosine A1 and A2A receptors. It is widely used in research for its neuroprotective, anti-inflammatory, and immunomodulatory properties, with applications in both in vitro and in vivo models of ischemia, inflammation, and pain.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number58-63-9
MW268.23
Purity99.56%
FormulaC10H12N4O5
SMILESOC[C@@H]1O[C@@H](C(O)C1O)N1C=NC2=C1N=CNC2=O
TargetAdenosine Receptor,ROS,Endogenous Metabolite
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (18.64 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:245 mg/mL (913.4 mM);H2O:43 mg/mL (160.31 mM)

Bioactivity

Target IC50
PvENT1:3.8 μM
In Vivo
METHODS: To study the analgesic effect of Inosine, Inosine (1 mg/kg, 10 mg/kg, and 100 mg/kg) was injected intraperitoneally to mice 20 min before formalin treatment. RESULTS: Inosine reduced formalin-induced leg withdrawal.
In Vitro
METHODS: Rat C6, DU-145, HaCaT, L6, and MCF7 cells were treated with Inosine (0-250 μM) for 48 hours, and MTT assay was used to detect the inhibition of cell growth. RESULTS: Inosine did not inhibit the growth of C6, DU-145, HaCaT, L6 and MCF7 cells at 250 μM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

XO, P1 receptor, disease, Adenosine Receptor, adenosine, AdenosineReceptor, antinociceptive, antihyperalgesic, antiallodynic, EndogenousMetabolite, Endogenous Metabolite, human, INO 495, INO495, INO-495, Inosine, Inhibitor, NSC 20262, inhibit, immunomodulatory, metabolite, metabolism, Parkinson's, NSC20262, NSC-20262, neuroprotective, nucleoside

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Key Properties

No computed properties available.

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Inosine (orb1310617)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% Tween 80 +
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1 g
¥ 910.00
1 ml x 10 mM (in DMSO)
¥ 910.00
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