Insulin efsitora alfa Antibody

SKU: orb1980410

Description

Insulin efsitora alfa (LY-3209590) is a selective insulin receptor (IR) agonist and fusion protein that combines a novel single-chain insulin variant with the structural domain of human IgG Fc for the study of type 2 diabetes. Insulin efsitora alfa Antibody is supplied for research use only and is intended for laboratory research involving animal models. Biorbyt supplies these products exclusively to research institutions and commercial laboratories.

Research Area

Signal Transduction

Images & Validation

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Key Properties

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CAS Number	2131038-11-2
MW	32.04 kDa
Purity	98.3% (SDS-PAGE); 98.1% (SEC-HPLC)
Target	IGF-1R

Bioactivity

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Target IC50	insulin receptor subtype B (human, IR-B ):391 nM (EC50)\|insulin receptor isoform A (human, IR-A):4241 nM (EC50)\|SAOS-2 cells:134 nM (EC50)\|H4IIE cells:20 nM (EC50) Read more...
In Vivo	In streptozotocin -treated diabetic rats, a single subcutaneous injection of Insulin efsitora alfa (3, 10, and 30 nmol/kg) significantly reduced blood glucose levels. Read more...
In Vitro	Insulin efsitora alfa stimulated the phosphorylation of human insulin receptor isoform A (hIR-A) and human insulin receptor subtype B (hIR-B) in HEK293 cells at concentrations ranging from 0.01 to 100 nM with EC50 values of 4241 nM and 391 nM, respectively. hIR-A and hIR-B were significantly dephosphorylated when treated with 20 µM for 30 min. Insulin efsitora alfa significantly promoted the dephosphorylation of hIR-A and hIR-B when treated at a concentration of 20 µM for 30 min. In addition, Insulin efsitora alfa stimulated lipogenesis in 3T3-L1 adipocytes as well as proliferation of SAOS-2 and H4IIE cells with EC50 values of 19 nM, 134 nM and 20 nM, respectively. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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LY3209590, LY-3209590, IGF1R, insulin receptor

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Gene Symbol

IGF-1R

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