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INT-767

SKU: orb1709407

Description

INT-767 is a potent dual agonist of the farnesoid X receptor (FXR) and TGR5, developed for NASH research. It has demonstrated efficacy in preclinical models, preventing steatohepatitis and promoting the browning of visceral adipose tissue alongside enhanced mitochondrial function in both in vitro and in vivo studies.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1000403-03-1
MW494.66
Purity98.00%
FormulaC25H43NaO6S
SMILESO[C@H]1[C@]2([H])[C@@](CC[C@]3([C@@]2([H])CC[C@]3([H])[C@H](C)CCOS(=O)([O-])=O)C)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])[C@H]1CC)C.[Na+]
TargetAutophagy,FXR,GPCR19
SolubilityDMSO:80 mg/mL (161.73 mM);H2O:80 mg/mL (161.73 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.67 mM)

Bioactivity

In Vivo
Mice were treated daily with INT-767 (10 and 20 mg/kg) or vehicle alone (40% 2-hydroxypropyl-β-cyclodextrin) via intraperitoneal injection for 2 weeks. The results showed that INT-767 reduced the levels of plasma total cholesterol, high-density lipoprotein cholesterol, and triglycerides in both db/m and db/db mice .
In Vitro
INT-767 does not inhibit hERG, indicating that this compound should not induce cardiac toxicity because of inhibition of the potassium channel.

Storage & Handling

Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

INT 767, INT767, INT-767, FXR, TGR5
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

INT-767 (orb1709407)

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(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

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