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IOWH-032

SKU: orb1305411

Description

IOWH-032 is a synthetic small molecule inhibitor of the CFTR chloride channel. It has been investigated in preclinical research for the treatment of secretory diarrheal diseases, including cholera, with studies demonstrating its efficacy in both in vitro assays and in vivo animal models of fluid secretion.

Research Area

Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1191252-49-9
MW545.18
Purity>99.99% (May vary between batches)
FormulaC22H15Br2N3O4
SMILESOc1c(Br)cc(cc1Br)-c1noc(n1)C(=O)NCc1ccc(Oc2ccccc2)cc1
TargetSARS-CoV,Autophagy,CFTR
SolubilityDMSO:93 mg/mL (170.59 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.05 mM)

Bioactivity

Target IC50
CFTR:1.01 μM
In Vivo
In T84-CFTR cells (IC50=6.87 μM), IOWH032 effectively inhibits CFTR activity.
In Vitro
In a closed-system mouse model, IOWH032 effectively inhibits the secretions induced by cholera toxin. Moreover, in a rat model with the cecum removed, IOWH032 (5 mg/kg) suppresses the excretion of waste.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SARS coronavirus, SARS-CoV, anti-diarrheal, Autophagy, ACE-2, Cystic fibrosis transmembrane conductance regulator, CFBE41o- WT cells, CFTR, IOWH 032, IOWH032, IOWH-032, inhibit, Inhibitor

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  • IOWH-032 [orb1226844]

    >98% (HPLC)

    1191252-49-9

    545.2

    C22H15Br2N3O4

    200 mg, 100 mg, 25 mg, 1 g, 500 mg, 10 mg, 50 mg
Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

IOWH-032 (orb1305411)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
¥ 1,040.00
10 mg
¥ 1,300.00
25 mg
¥ 1,820.00
50 mg
¥ 2,470.00
100 mg
¥ 3,510.00
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