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IPAG

SKU: orb1704460

Description

IPAG is a small molecule σ-receptor antagonist with a pKi of 4.3. It has been utilized in research to study apoptosis induction and σ-receptor function in various in vitro cellular models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number193527-91-2
MW395.28
Purity99.65%
FormulaC17H22IN3
SMILESIc1ccc(NC(=N)NC2C3CC4CC(C3)CC2C4)cc1
TargetOpioid Receptor,Sigma receptor
SolubilityDMSO:7.5 mg/mL (18.97 mM)

Bioactivity

In Vitro
IPAG treatment produces a mean of 100±8 μg per 106 cells. IPAG can inhibit cell proliferation. Treatment with IPAG decreases cell mass. IPAG treatment suppresses phosphorylation of translational regulator proteins p70S6K, S6, and 4E-BP1. Sigma1 inhibition by IPAG causes the autolysosomal degradation of PD-L1 in PC3 (hormone-insensitive prostate cancer) and MDA-MB-231 (triple-negative breast cancer) cell lines and reduces the levels of functional PD-L1 on the surface of the cells.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

IPAG, OpioidReceptor, Opioid Receptor, δ-opioid receptor
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Key Properties

No computed properties available.

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Protocol Information

IPAG (orb1704460)

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Available Sizes

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1 mg
¥ 1,040.00
5 mg
¥ 1,690.00
10 mg
¥ 2,340.00
25 mg
¥ 4,160.00
50 mg
¥ 6,760.00
100 mg
¥ 9,490.00
DispatchUsually dispatched within 3-5 working days
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