Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

Ipidacrine

SKU: orb1299409

Description

Ipidacrine (NIK-247) is a small molecule compound investigated as a potential therapeutic agent for dementia. Its research applications include in vitro studies on cholinesterase inhibition and in vivo models for evaluating cognitive enhancement, primarily within the field of neurodegenerative disease research.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

−
Ipidacrine

Key Properties

−
CAS Number62732-44-9
MW188.27
Purity97.73% (May vary between batches)
FormulaC12H16N2
SMILESNc1c2CCCc2nc2CCCCc12
TargetOthers
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (5.31 mM);DMSO:10 mg/mL (53.12 mM)

Bioactivity

−
In Vivo
A single oral administration of ipidacrine (0.3 and 1 mg/kg) reduced the increased total latency induced by scopolamine in this task. The repeated administration of ipidacrine (1 mg/kg) of once a day for 5 successive days reduced the increased total latency induced by scopolamine to the levels of the saline-treated control rats in this task.Ipidacrine was rapidly taken up into the brain within 5 min. Moreover, higher drug levels were observed mainly in the cortex and hippocampus, which both play important roles in learning and memory. Thus, a previous study together with this investigation indicate that ipidacrine improves amnesia which consists of the impairment of the working and reference memory in various animal models, suggesting that ipidacrine is a useful candidate for the therapy of patients with Alzheimer's disease.

Storage & Handling

−
Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

−
Inhibitor, Ipidacrine, inhibit, nootropic, NIK‐247, Cholinesterase (ChE), cholinesterase, Alzheimer disease
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
604519 ↗

Key Properties

−
No computed properties available.

Protocol Information

Find More Protocols

Available Sizes

Select a size below

50 mg
Enquire
1 ml x 10 mM (in DMSO)
$ 70.00
25 mg
$ 70.00
Bulk Enquiry
Need technical support? Find your Distributor Return and Tax Policy

Email

[email protected]

UK Office

+44 (0)1223 859353

US Office

+1 (415) 906-5211

CN Office

+86 (27)-87663101

Distributors

biorbyt.com/distributor