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Isofistularin-3

SKU: orb1992821

Description

Isofistularin-3 is a direct, DNA-competitive inhibitor of DNMT1 (IC50 = 13.5 µM) that acts as a DNA demethylating agent. Its mechanism induces cell cycle arrest and sensitizes cancer cells to TRAIL-induced apoptosis in vitro, supporting its investigation as a potential cytotoxin for antibody-drug conjugates (ADCs) in oncology research.

Research Area

Cell Biology, Epigenetics & Chromatin

Images & Validation

Key Properties

MW1114.01
FormulaC31H30Br6N4O11
SMILESCOC1=C(Br)[C@H](O)[C@@]2(ON=C(C(NC[C@H](O)COC3=C(Br)C=C([C@H](O)CNC(C4=NO[C@]5(C4)C=C(Br)C(OC)=C(Br)[C@H]5O)=O)C=C3Br)=O)C2)C=C1Br
TargetAutophagy,DNA Methyltransferase,Apoptosis,ADC Cytotoxin

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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Isofistularin-3 (orb1992821)

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