Isolithocholic Acid

SKU: orb1694310

Description

Isolithocholic acid (3-Epilithocholic acid) is a microbial metabolite and stereoisomer of lithocholic acid. This secondary bile acid is used in research to study bile acid metabolism, receptor interactions (e.g., TGR5), and their roles in gastrointestinal and metabolic diseases in experimental models.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	1534-35-6
MW	376.57
Purity	99.40% (May vary between batches)
Formula	C₂₄H₄₀O₃
SMILES	[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(O)=O
Target	Endogenous Metabolite
Solubility	Ethanol:Slightly soluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.66 mM);Chloroform:Slightly soluble;Methanol:Slightly soluble;DMSO:13.51 mg/mL (35.88 mM)

Bioactivity

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In Vivo

Fecal Isolithocholic Acid levels significantly decrease starting from day 28 in the high fat diet (HFD) group when compared to rats on a normal diet.

In Vitro

Isolithocholic Acid at a concentration of 0.01% does not inhibit the spore germination and outgrowth in CF5 and M120 strains, but at a higher concentration of 0.1%, it significantly inhibits these processes. At a much lower concentration (0.00003%), it prevents the growth of CD196, M68, CF5, 630, and BI9 strains, while also substantially reducing toxin activity in CF5, BI9, M120, and 630 strains. Furthermore, a slightly higher concentration of Isolithocholic Acid (0.0003%) results in a significant decrease in toxin activity across all strains, with the exception of R20291 and M120.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Endogenous Metabolite, EndogenousMetabolite, isoLCA, Isolithocholic Acid, beta-Lithocholic acid, b-Lithocholic acid, 3β-Hydroxy-5β-cholanic acid, 3beta-Hydroxy-5beta-cholanic acid, 3b-Hydroxy-5b-cholanic acid, 3-Epilithocholic acid, β-Lithocholic acid

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Compound Identifiers

PubChem CID

164853 ↗

Key Properties

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No computed properties available.

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