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Isosilybin A

SKU: orb1297319

Description

Isosilybin A is a partial PPARγ agonist that upregulates ABCA1 expression and inhibits tyrosinase activity. It exhibits anti-angiogenic and anti-prostate cancer properties through cell cycle arrest and apoptosis, making it a candidate for research in oncology, dermatology, and metabolic studies.

Research Area

Cell Biology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Images & Validation

Key Properties

CAS Number142796-21-2
MW482.44
Purity99.88% (May vary between batches)
FormulaC25H22O10
SMILESCOc1cc(ccc1O)[C@H]1Oc2ccc(cc2O[C@@H]1CO)[C@H]1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O
TargetTyrosinase,ABC Transporter,ERK,p38 MAPK,Androgen Receptor,NF-κB,Apoptosis,PPAR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.84 mM);DMSO:90 mg/mL (186.55 mM)

Bioactivity

In Vitro
To investigate the effects of milk thistle extract and its main flavonolignans (silybin A, silybin B, Isosilybin A and isosilybin B) on CYP2C8 activity at relevant concentrations, the effect of milk thistle extract and the flavonolignans on CYP2C8 enzyme activity was studied in vitro using human liver microsomes (HLM) incorporating an enzyme-selective substrate for CYP2C8, amodiaquine. Metabolite formation was analyzed using liquid chromatography-tandem mass spectrometry (LC/MS-MS). The concentration causing 50% inhibition of enzyme activity (IC50) was used to express the degree of inhibition. Isosilibinin, a mixture of the diastereoisomers Isosilybin A and isosilybin B, was found to be the most potent inhibitor, followed by isosilybin B with IC50 values (mean ± SE) of 1.64 ± 0.66 μg/mL and 2.67 ± 1.18 μg/mL, respectively. The rank order of observed inhibitory potency after isosilibinin was silibinin > Isosilybin A > silybin A > milk thistle extract > and silybin B

Storage & Handling

Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PPARγ, Tyrosinase, inhibit, Isosilybin A, Inhibitor, ABCA1, Apoptosis

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Key Properties

No computed properties available.

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Isosilybin A (orb1297319)

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Available Sizes

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1 mg
¥ 1,560.00
5 mg
¥ 3,120.00
1 ml x 10 mM (in DMSO)
¥ 3,380.00
10 mg
¥ 4,420.00