ITCH (N1) Antibody, Rabbit Polyclonal

SKU: orb67190

Description

Rabbit polyclonal to ITCH.E3 ubiquitin-protein ligase Itchy homolog (ITCH) acts as an E3 ubiquitin-protein ligase. ITCHubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway. It isinvolved in the negative regulation of MAVS-dependent cellular antiviral responses. ITCH is involvedin the regulation of apoptosis and reactive oxygen species levels through the ubiquitination andproteasomal degradation of TXNIP. It mediates the antiapoptotic activity of epidermal growth factorthrough the ubiquitination and proteasomal degradation of p15 BID. Defects in ITCH are the cause ofsyndromic multisystem autoimmune disease (SMAD).

Research Area

Apoptotic, Cancer, Epigenetics, Immunology, Infectious Diseases, Neuroscience, Signaling Pathways

Images & Validation

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Item 1 of 1

Tested Applications	WB
Dilution Range	WB:1:500-1:1000
Reactivity	Human

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	N-terminal region of human ITCH
Molecular Weight	103
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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anti-ITCH antibody,anti-E3 ubiquitinprotein ligase Itchy homolog antibody,anti-Atrophin1interacting protein 4 antibody,anti-AIP4 antibody,anti-NFE2associated polypeptide 1 antibody,anti-NAPP1 antibody

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Western blot analysis of total cell extracts from human Hela using ITCH antibody

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UniProt

Q96J02

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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