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JAK-IN-14

SKU: orb1685227

Description

JAK-IN-14 (compound 16) is a potent and selective JAK1 inhibitor (IC50 <5 μM) with over 8-fold selectivity against JAK2/JAK3. It functions by binding the JAK1 active site to inhibit its phosphorylation. This inhibitor is a valuable research tool for studying immune, inflammatory, and oncological pathways in both cellular and animal models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1973485-06-1
MW334.35
FormulaC19H15FN4O
SMILESFc1cc(CC#N)ccc1-c1cccc2nc(NC(=O)C3CC3)cn12
TargetOthers
SolubilityDMSO:5 mg/mL (14.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.99 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

JAK IN 14, JAK-IN-14, JAKIN14
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Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

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100 mg
$ 1,610.00
DispatchUsually dispatched within 5-10 working days
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