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JAK-IN-40

SKU: orb2945032

Description

JAK-IN-40 (Compound 46) is a pan-JAK inhibitor with low micromolar IC50 values against JAK1-3. It suppresses STAT3 phosphorylation, inhibits cancer cell proliferation, induces G2/M arrest and apoptosis, and shows synergistic anti-tumor activity with Osimertinib in vitro. This compound is a useful tool for researching JAK/STAT signaling in oncology.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

MW536.65
FormulaC26H32N8O3S
TargetJAK,Apoptosis,STAT

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

JAK-IN-40 (orb2945032)

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