Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

JAK-IN-40

SKU: orb2945032

Description

JAK-IN-40 (Compound 46) is a pan-JAK inhibitor with low micromolar IC50 values against JAK1-3. It suppresses STAT3 phosphorylation, inhibits cancer cell proliferation, induces G2/M arrest and apoptosis, and shows synergistic anti-tumor activity with Osimertinib in vitro. This compound is a useful tool for researching JAK/STAT signaling in oncology.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

MW536.65
FormulaC26H32N8O3S
TargetSTAT,JAK,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Protocol Information