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JAK1-IN-4

SKU: orb1707166

Description

JAK1-IN-4 is a potent and selective JAK1 inhibitor, demonstrating an IC50 of 85 nM for JAK1 with significant selectivity over JAK2 and JAK3. It effectively suppresses STAT3 phosphorylation in cellular assays, such as in NCI-H1975 cells (IC50 = 227 nM), making it a useful research tool for studying JAK-STAT signaling in oncology and immunology research.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number2091134-35-7
MW521.59
FormulaC26H32FN9O2
SMILESN(C([C@@H](C)N1C[C@@H](C)N(C)CC1)=O)C2=C3C(C(=CN3)C4=NC(NC=5C(OC)=NN(C)C5)=NC=C4F)=CC=C2
TargetJAK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Quality Guarantee

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Key Properties

No computed properties available.

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JAK1-IN-4 (orb1707166)

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