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JAK1-IN-8

SKU: orb1694218

Description

JAK1-IN-8 is a potent and selective Janus kinase 1 (JAK1) inhibitor with an IC50 value below 500 nM. This small molecule is a valuable research tool for investigating JAK-STAT signaling pathways in both cellular and animal models of inflammation and autoimmune diseases.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1973485-18-5
MW442.51
Purity98.40%
FormulaC22H23FN4O3S
SMILESFc1cc(ccc1CN1CCS(=O)(=O)CC1)-c1cccc2nc(NC(=O)C3CC3)cn12
TargetJAK
SolubilityDMSO:112.5 mg/mL (254.23 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.04 mM)

Bioactivity

Target IC50
JAK3:>5000 nM|JAK2:500-1000 nM|JAK1:<500 nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

JAK1IN8, JAK-1-IN-8, JAK1-IN-8, JAK1, JAK1 IN 8
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

JAK1-IN-8 (orb1694218)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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5 mg
¥ 1,040.00
1 ml x 10 mM (in DMSO)
¥ 1,170.00
10 mg
¥ 1,560.00
25 mg
¥ 2,470.00
50 mg
¥ 4,030.00
100 mg
¥ 6,370.00
200 mg
¥ 8,320.00
DispatchUsually dispatched within 3-5 working days
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