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JAK1/STAT3-IN-1

SKU: orb2944713

Description

JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

MW548.67
FormulaC30H33FN4O3S
TargetSTAT,JAK

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Protocol Information

JAK1/STAT3-IN-1 (orb2944713)

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