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JAK1/TYK2-IN-5

SKU: orb3173026

Description

JAK1/TYK2-IN-5 (compound A1) is an inhibitor of JAK1 and TYK2, exhibiting Ki values of 0.0044 nM for TYK2JH2, 0.02 nM for JAK1 JH2, 6.9 μM for JAK1 JH1, 0.79 μM for JAK2 JH1, 0.21 μM for JAK3 JH1, and 0.55 μM for TYK2JH1. Additionally, it inhibits STAT activation mediated by TYK2/JAK1, induced by IFNα.

Images & Validation

Key Properties

CAS Number3026367-07-4
MW535.55
FormulaC26H30N7O4P
SMILESO=C(N)C1=NN=C(C=C1NC2=CC=CC(C3=NN(C(=C3)P(=O)(C4CC4)C5CC5)C)=C2OC)NC(=O)C6CC6
TargetJAK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information