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JAK2-IN-14

SKU: orb3173063

Description

JAK2-IN-14 is an orally effective JAK2 inhibitor with an IC50 of 2 nM. It exhibits selectivity for JAK2 over JAK1, JAK3, and TYK2 by factors of 89.5, 80.5, and 51 times, respectively. JAK2-IN-14 inhibits the STAT5 signaling pathway and can cause tumor cell cycle arrest and apoptosis (apoptosis). It is applicable in the research of myeloproliferative neoplasms (MPN).

Images & Validation

Key Properties

CAS Number3087335-24-5
MW459.6
FormulaC26H33N7O
SMILESN1=CC(=C2NC1=NC=3C=CC(=C(OCCCCN4N=CC2=C4)C3)N5CCN(CC5)CC6CC6)C
TargetSTAT,JAK,Apoptosis

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information