Cart summary

You have no items in your shopping cart.

JAK2-IN-6

SKU: orb1690587

Description

JAK2-IN-6 is a potent and selective aminothiazole-based JAK2 inhibitor (IC50 = 22.86 µg/mL) with antiproliferative effects, showing no activity against JAK1/JAK3. It is a valuable research tool for studying JAK2-driven signaling in pathologies like myeloproliferative neoplasms and for conducting in vitro cellular proliferation assays.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number353512-04-6
MW335.83
Purity99.64%
FormulaC14H10ClN3OS2
SMILESNc1nc(Nc2ccccc2)sc1C(=O)c1ccc(Cl)s1
TargetJAK
SolubilityDMSO:55 mg/mL (163.77 mM)

Bioactivity

Target IC50
JAK2:22.86 μg/mL
In Vitro
The treatment of JAK2-IN-6 (Compound B2; 6.3-50 μg/mL; 48 hours) demonstrates significant antiproliferative activity against PC-9, H1975, and PANC-1 cell lines. The IC50 values for PC-9, H1975, and PANC-1 cell lines are 18.1 μg/mL, 58.3 μg/mL, and 40.6 μg/mL, respectively .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

JAK2, JAK2IN6, JAK-2-IN-6, JAK2-IN-6, JAK2 IN 6
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

JAK2-IN-6 (orb1690587)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 910.00
5 mg
¥ 1,560.00
10 mg
¥ 2,080.00
25 mg
¥ 3,120.00
50 mg
¥ 4,420.00
100 mg
¥ 6,370.00
200 mg
¥ 8,970.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry