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JAK3-IN-18

SKU: orb3136193

Description

JAK3-IN-18 is a selective and orally active dual inhibitor targeting JAK3 and TEC, with IC50 values of 0.5391 nM and 12.40 nM, respectively. It demonstrates remarkable selectivity for AK1, AK2, and TYK2, with selectivity ratios exceeding 10,000-fold. JAK3-IN-18 exhibits exceptional therapeutic efficacy in a mouse model of experimental autoimmune encephalomyelitis and is applicable for multiple sclerosis research.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number2914873-59-7
MW337.35
FormulaC18H16FN5O
SMILESN([C@@H]1C=2C(CN(C(C=C)=O)C1)=CC(F)=CC2)C3=C4C(NC=C4)=NC=N3
TargetJAK,Tyrosinase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information