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JHU37160

SKU: orb1298442

Description

JHU37160 is a potent and selective DREADD agonist, exhibiting high affinity and efficacy at both hM3Dq and hM4Di receptors. This tool compound is widely used in neuroscience research for the chemogenetic manipulation of specific neuronal circuits in both in vitro cellular assays and in vivo animal models to study behavior and neural function.

Research Area

Neuroscience

Images & Validation

Key Properties

CAS Number2369979-68-8
MW358.84
Purity99.25% (May vary between batches)
FormulaC19H20ClFN4
SMILESCCN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c(F)cccc12
TargetAChR
SolubilityDMSO:72 mg/mL (200.65 mM);Ethanol:72 mg/mL (200.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.57 mM)

Bioactivity

Target IC50
M3Dq DREADD (human):18.5 nM (EC50)|M4Di DREADD (human):0.2 nM (EC50)
In Vivo
JHU 37160 exhibits high in vivo DREADD potency. It exhibits selective [3H]clozapine displacement from DREADDs in brain tissue from WT and D1-DREADD mice
In Vitro
JHU 37160 is a potent agonist of DREADD with high potency and efficacy in fluorescent and BRET-based assays in HEK-293 cells, whereas no responses are observed in untransfected HEK-293 cells

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Clozapine, DREADD, M3 mAChR, mAChR, Inhibitor, Muscarinic acetylcholine receptor, JHU37160, JHU-37160, JHU 37160, inhibit, hM3Dq, hM4Di
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 80.00
10 mg
$ 90.00
25 mg
$ 120.00
50 mg
$ 170.00
100 mg
$ 240.00
DispatchUsually dispatched within 3-5 working days
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