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JI069

SKU: orb1944746

Description

JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number850019-35-1
MW387.24
Purity98.01%
FormulaC15H12Cl2N2O4S
SMILESO=C(N)C=1C=CSC1NC(=O)COC(=O)CC=2C(Cl)=CC=CC2Cl
TargetJAK,STAT
SolubilityDMSO:25 mg/mL (64.56 mM)

Bioactivity

In Vivo
JI069 (25mg/kg weight; i.p.; 6-week-old DBA/1J mice) suppressed symptoms of collagen-induced arthritis (CIA) model in mice and inhibited the cytokine production from T cells as well as the STAT3 phosphorylation of synovial cells.
In Vitro
In HEK293T cells and primary T cells, JI069 (1-10 μM) suppressed STAT3 activation as efficiently as other STATs, including STAT1, STAT5, and STAT6. JI069 effectively suppressed Th1, Th2, and Th17 differentiation while strongly promoting Treg differentiation.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

JI 069, JI069, JI-069, JAK, STAT, WAY354189, WAY-354189, WAY 354189
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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JI069 (orb1944746)

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Available Sizes

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5 mg
¥ 1,040.00
10 mg
¥ 1,300.00
25 mg
¥ 2,080.00
50 mg
¥ 2,990.00
100 mg
¥ 4,420.00
DispatchUsually dispatched within 3-5 working days
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