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JND4135

SKU: orb2665332

Description

JND4135 is a potent type II TRK inhibitor with low nanomolar IC50 values against TRKA, TRKB, and TRKC. It effectively overcomes mutation-mediated resistance, inhibits downstream signaling, and induces cell cycle arrest and apoptosis in vitro, while also demonstrating in vivo antitumor efficacy in a BaF3-CD74-TRKA-G667C xenograft model.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number2366216-76-2
MW597.75
FormulaC37H39N7O
SMILESO=C(NC=1C=C(C=C(C1)C(C)C)CN2CCN(C)CC2)C=3C=CC=C(C#CC4=CN=C5C=NC(=CN45)C=6C=CC(N)=CC6)C3C
TargetApoptosis,Trk receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

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Protocol Information

JND4135 (orb2665332)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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