JPH203

SKU: orb1309522

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Description

JPH203 dihydrochloride, also known as KYT-0353, is a tyrosine-based selective inhibitor of the L-type amino acid transporter 1 (LAT1). It is utilized in cancer research to investigate LAT1 function and inhibit tumor cell proliferation in both in vitro and in vivo experimental models.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	1597402-27-1
MW	545.2
Purity	>98%
Formula	C₂₃H₁₉Cl₂N₃O₄·2HCl
SMILES	C1=CC=C(C=C1)C2=NC3=CC(=CC(=C3O2)COC4=C(C=C(C=C4Cl)C[C@@H](C(=O)O)N)Cl)N.Cl.Cl
Target	Others
Solubility	Soluble in DMSO (up to at least 25 mg/ml)

Bioactivity

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In Vivo

JPH203 exhibits dose-dependent inhibition on HT-29 tumor growth in nude mice.

In Vitro

JPH203 (30 mM) induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells. JPH203 (0.001-100 μM) inhibits 14C-leucine (1.0 μM) uptake slightly in FOB cells with an IC50 value of 92.12 ± 10.71 μM, but potently exihibts such effects in Saos2 cells with an IC50 value of 1.31 ± 0.27 μM. JPH203 (0.01 to 30 mM, 1-4 d) potently inhibits cell proliferation in Saos2 cells in a dose- and time-dependent manner, with an IC50 of 4.09-0.09 mM, but slightly inhibits that of FOB cells, with an IC50 of 24.1-2.8 mM.JPH203 Dihydrochloride is a selective inhibitor of LAT1. JPH203 inhibits 14C-leucine uptake in S2-hLAT1 and HT-29 cells, with IC50s of 0.14 μM and 0.06 μM. JPH203 (3-1000 μM) exhibits concentration-dependent inhibitory effects on S2-hLAT1 cell growth with an IC50 of 16.4 μM. JPH203 also displays inhibitory activities against HT-29 cell growth, with an IC50 value of 4.1 μM. JPH203 (0.001-100 μM) inhibits the 14C-leucine (1.0 μM) uptake in a concentration dependent way by the YD-38 cells with an IC50 value of 0.79 ± 0.06 μM. JPH203 slightly shows such effects in normal human oral keratinocytes (NHOKs). JPH203 (0.01-30 mM, 1-4 d) completely inhibits the proliferation of YD-38 cells in a dose- and time-dependent manner. However, JPH203 slightly inhibits the proliferation of NHOKs. JPH203 (30 mM) induces apoptosis of YD-38 cells. JPH203 (3 mM) also increases the level of cleaved PARP in activation of the caspases cascade.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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KYT-0353; Nanvuralant

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Compound Identifiers

PubChem CID

122553374 ↗

Key Properties

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No computed properties available.

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JPH203 (orb1309522)

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Purity:	99.70% (May vary between batches)
CAS Number:	1037592-40-7
MW:	472.32
Formula:	C₂₃H₁₉Cl₂N₃O₄

Purity:	>98% (HPLC)
CAS Number:	1597402-27-1
MW:	545.24
Formula:	C₂₃H₂₁Cl₄N₃O₄

JPH203

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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JPH203 (orb1309522)

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