K-Opioid receptor agonist-1

SKU: orb2564488

Description

Compound 5a is a potent and brain-penetrant κ-opioid receptor agonist (Kᵢ = 0.25 nM, EC₅₀ = 2 nM) with a brain/plasma ratio of 0.50-0.65. It demonstrates anti-inflammatory activity in preclinical models of arachidonic acid- and oxazolidinone-induced dermatitis, supporting research in neuropharmacology and inflammatory skin disease.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	1816990-29-0
MW	454.39
Formula	C₂₂H₂₉Cl₂N₃O₃
SMILES	C(CC1=CC(Cl)=C(Cl)C=C1)(=O)N2[C@]3([C@@](N(C(OC)=O)CC2)(CCC[C@@H]3N4CCCC4)[H])[H]
Target	Opioid Receptor

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

86280667 ↗

Key Properties

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No computed properties available.

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