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Kainic acid

SKU: orb1707144

Description

Kainic acid is an excitatory amino acid receptor agonist (EC50=16.2 μM). Kainic acid is an effective excitatory toxic agent. Kainic acid induces epileptic seizures.

Images & Validation

Key Properties

CAS Number487-79-6
MW213.23
Purity98.47%
FormulaC10H15NO4
SMILESCC(=C)[C@H]1CNC([C@H]1CC(O)=O)C(O)=O
TargetOthers
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (11.72 mM);H2O:50 mg/mL (234.49 mM)

Bioactivity

Target IC50
Glutamate receptor 6 (HEK293 cells):0.7 μM (EC50)|Glutamate receptor 5 (HEK293 cells):16.2 μM (EC50)|Neuron:17.3 μM (EC50)
In Vivo
METHODS: To study the effect of Kainic acid on epileptic seizures, Kainic acid (30 mg/kg) was intraperitoneally injected into juvenile (20 mg/kg) or adult (30 mg/kg) male Slack+/+ and Slack−/− mice. RESULTS: After injection of 30 mg/kg of Kainic acid, grade 3 or above epileptic seizures occurred in mice within 20 minutes. Different mouse strains have different sensitivities to Kainic acid. For example, Slack - / - mice are more prone to severe epileptic seizures and status epilepticus (SE), and have a higher mortality rate than Slack+/+ mice.
In Vitro
METHODS: After the NSC-34 mouse motor neuron cell line was treated with Kainic acid (0.1 mM, 0.5 mM, 1 mM) for 24 and 48 hours, the cell viability was detected by the MTT method. RESULTS: Kainic acid induced excitotoxic injury, with an IC50 value of approximately 0.5 mM.

Storage & Handling

Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, Kainic acid, inhibit

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Key Properties

No computed properties available.

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Kainic acid (orb1707144)

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% Tween 80 +
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10 mg
¥ 3,250.00
50 mg
¥ 9,230.00
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