KDM1A (M) Antibody, Rabbit Polyclonal

SKU: orb66998

Description

Rabbit polyclonal to KDM1A.Lysine-specific histone demethylase 1A (KDM1A) is a histone demethylase that demethylates both'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or acorepressor, depending on the context. KDM1A acts as a corepressor by mediating demethylation ofH3K4me, a specific tag for epigenetic transcriptional activation. KDM1A can demethylate both mono-(H3K4me1) and di-methylated (H3K4me2) H3K4me, and may play a role in the repression of neuronalgenes. KDM1A also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, bybeing recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag forepigenetic transcriptional repression. KDM1A is required for gastrulation during embryogenesis.

Research Area

Developmental Biology, Epigenetics

Images & Validation

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Item 1 of 1

Tested Applications	WB
Dilution range	WB:1:1000-1:5000
Reactivity	Human, Mouse

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	middle region of human KDM1A
Molecular Weight	93
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Disclaimer	For research use only

Alternative Names

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anti-KDM1A antibody,anti-Lysinespecific histone demethylase 1A antibody,anti-BRAF35HDAC complex protein BHC110 antibody,anti-Flavincontaining amine oxidase domaincontaining protein 2 antibody,anti-AOF2 antibody,anti-KDM1 antibody,anti-KIAA0601 antibody,anti-LSD1 antibody

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Western blot analysis of total cell extracts from human Hela(Lane1),human Jurkat(Lane2) and mouse thymus(Lane3) using KDM1A antibody

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UniProt

O60341

UniProt Details

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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