KDM3A (C) Antibody, Rabbit Polyclonal

SKU: orb67001

Description

Rabbit polyclonal to KDM3A.Lysine-specific histone demethylase 3A (KDM3A) is a histone demethylase that specificallydemethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. KDM3Apreferentially demethylates mono-and dimethylated H3 'Lys-9' residue, with a preference fordimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. KDM3A is involvedin hormone-dependent transcriptional activation, by participating in recruient to androgen-receptortarget genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. KDM3A has beenimplicated in spermatogenesis by regulating expression of target genes such as PRM1 and P1,which are required for packaging and condensation of sperm chromatin. KDM3A is also involved inobesity resistance through regulation of metabolic genes such as PPARA and UCP1.

Research Area

Epigenetics

Images & Validation

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Tested Applications	WB
Dilution range	WB:1:1000-1:3000
Reactivity	Human

Key Properties

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Host	Rabbit
Clonality	Polyclonal
Immunogen	C-terminal region of human KDM3A
Molecular Weight	147
Purity	Affinity purification
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	0.01% NaN3
Disclaimer	For research use only

Alternative Names

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anti-KDM3A antibody,anti-Lysinespecific demethylase 3A antibody,anti-JmjC domaincontaining histone demethylation protein 2A antibody,anti-Jumonji domaincontaining protein 1A antibody,anti-JHDM2A antibody,anti-JMJD1 antibody,anti-JMJD1A antibody,anti-KIAA0742 antibody,anti-TSGA antibody

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Western blot analysis of total cell extracts from human Jurkat(Lane) and human T47D(Lane2) using KDM3A antibody

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UniProt

Q9Y4C1

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No UniProt data available

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Protocol Information

Western Blot (IB, immunoblot)

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