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KIT/PDGFRA-IN-1

SKU: orb2944353

Description

KIT/PDGFRA-IN-1 (compound 19) is a dual inhibitor of wild-type and mutant KIT and PDGFRA kinases, with IC50 values ranging from sub-micromolar to high micromolar across various isoforms. Its cellular activity, demonstrated by GR50 values in GIST lines, supports its use as a research tool for investigating tyrosine kinase signaling in cancers like gastrointestinal stromal tumors.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

MW489.449
FormulaC26H18F3N5O2
SMILESCC(C=CC(C(NC1=CC(C(F)(F)F)=C(NC(C=C)=O)C=C1)=O)=C2)=C2C#CC3=CN=C4N3N=CC=C4
TargetPDGFR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

KIT/PDGFRA-IN-1 (orb2944353)

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