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Description
Research Area
Images & Validation
−![[KO Validated] HELLS Rabbit pAb](/images/quality_badge_antibodies.png)
| Tested Applications | WB |
|---|---|
| Dilution Range | WB: 1:500-2000, IHC-P: 1:50-200, IF/ICC: 1:50-200, IP: 1:50-200, ChIP: 1:20-100 |
| Reactivity | Human, Mouse, Rat |
Key Properties
−| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant fusion protein of human HELLS (NP_060533.2). |
| Molecular Weight | 120kDa |
| Purity | Affinity purification |
| Conjugation | Unconjugated |
Storage & Handling
−| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
|---|---|
| Buffer/Preservatives | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
| Concentration | 1 mg/ml |
| Expiration Date | 12 months from date of receipt. |
| Disclaimer | For research use only |
Alternative Names
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Quality Guarantee
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Annalisa Tameni 1, Selene Mallia 1, Veronica Manicardi 1, Benedetta Donati 1, Federica Torricelli 1, Emanuele Vitale 1 2, Elisa Salviato 1, Giulia Gambarelli 1, Silvia Muccioli 1, Magda Zanelli 3, Stefano Ascani 4, Giovanni Martino 4 5, Francesca Sanguedolce 6, Elisabetta Sauta 7, Ione Tamagnini 3, Noemi Puccio 1, Antonino Neri 8, Alessia Ciarrocchi 1, Valentina Fragliasso HELLS regulates transcription in T-cell lymphomas by reducing unscheduled R-loops and by facilitating RNAPII progression Nucleic Acids Res, 10, gkae239 (2024)
Applications
Reactivity
Tameni, Annalisa et al. The DNA-helicase HELLS drives ALK- ALCL proliferation by the transcriptional control of a cytokinesis-related program Cell Death Dis, 12, 130 (2021)