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KPT-251

SKU: orb1305499

Description

KPT-251 is a small molecule that potently and selectively inhibits nuclear export. It is utilized in cancer research, particularly in studies of leukemia and solid tumors, to investigate the biological consequences of XPO1 inhibition in both cellular and animal models.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1388841-50-6
MW375.23
Purity98.54% (May vary between batches)
FormulaC14H7F6N5O
SMILESC(F)(F)(F)C=1C=C(C=C(C(F)(F)F)C1)C2=NN(/C=C\C3=NN=CO3)C=N2
TargetOthers,CRM1,Apoptosis
SolubilityDMSO:65 mg/mL (173.23 mM)

Bioactivity

In Vivo
In a systemic metastasis model, following intracardiac injection of PCb2 cells, 80% (8/10) of controls, 10% (1/10) Selinexor- and 20% (2/10) KPT-251-treated animals developed radiographic evidence of lytic bone lesions. Similarly, after intra-tibial injection, the lytic areas were higher in controls than in Selinexor and KPT-251 groups. Analogously, the serum levels of osteoclast markers (mTRAP and type I collagen fragment, CTX), were significantly higher in controls than in Selinexor- and KPT-251-treated animals. Importantly, overall survival and disease-free survival were significantly higher in Selinexor- and KPT-251-treated animals when compared to controls.
In Vitro
Treatment of Glioblastoma neurosphere cultures with KPT-251 revealed dose-responsive growth inhibition in seven patient-derived GBM lines.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

A375, antileukemic activity, Apoptosis, CRM1, Chromosomal Maintenance 1, KPT 251, KPT251, KPT-251, myeloid leukemia, inhibit, nuclear export, Inhibitor, melanoma, Exportin 1, XPO1
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Key Properties

No computed properties available.

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Protocol Information

KPT-251 (orb1305499)

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Available Sizes

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1 mg
¥ 2,340.00
2 mg
¥ 2,860.00
5 mg
¥ 4,160.00
1 ml x 10 mM (in DMSO)
¥ 4,420.00
10 mg
¥ 5,720.00
25 mg
¥ 9,100.00
50 mg
¥ 12,610.00
DispatchUsually dispatched within 3-5 working days
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