Cart summary

You have no items in your shopping cart.

KS176

SKU: orb1304036

Description

KS176 is a potent and selective BCRP (ABCG2) inhibitor that does not affect P-glycoprotein or MRP1. It is a valuable chemical probe for studying multidrug resistance and drug disposition in breast cancer and other malignancies, applicable in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1253452-78-6
MW405.4
Purity99.61%
FormulaC22H19N3O5
SMILESOCCc1ccc(NC(=O)c2ccccc2NC(=O)c2ccc(cc2)[N+]([O-])=O)cc1
TargetPotassium Channel,BCRP
SolubilityDMSO:55 mg/mL (135.67 mM)

Bioactivity

Target IC50
BCRP(Pheo A):0.59 μM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Potassium Channel, PotassiumChannel, Inhibitor, inhibit, KS176, KS-176, KS 176, BCRP, BKCa-channel, ABCG2, Breast cancer resistance protein
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

KS176 (orb1304036)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
¥ 910.00
1 ml x 10 mM (in DMSO)
¥ 1,170.00
5 mg
¥ 1,170.00
10 mg
¥ 1,560.00
25 mg
¥ 2,860.00
50 mg
¥ 4,810.00
100 mg
¥ 6,630.00
200 mg
¥ 8,970.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry