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Kv7.2/Kv7.3 agonist 1

SKU: orb2695488

Description

Compound 16 is an orally active, small-molecule agonist of Kv7.2/Kv7.3 (KCNQ2/3) potassium channels with an in vitro EC50 of 1.03 µM. It shows in vivo efficacy, providing analgesia in mouse models of neuropathic pain, including chronic constriction injury and diabetic peripheral neuropathy.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2315450-35-0
MW275.28
FormulaC14H14FN3O2
SMILESO=C(NC1=NC(OCC2=CC=C(F)C=C2)=CC=C1N)C
TargetPotassium Channel

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Key Properties

No computed properties available.

Protocol Information

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25 mg
$ 1,560.00
50 mg
$ 2,020.00
100 mg
$ 2,540.00
DispatchUsually dispatched within 5-10 working days
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