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L 006235

SKU: orb1219464

Description

L 006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.

Images & Validation

Key Properties

CAS Number294623-49-7
MW466.6
Purity>98% (HPLC)
FormulaC24H30N6O2S
SMILESCN1CCN(CC1)c1nc(cs1)-c1ccc(cc1)C(=O)NC1(CCCCC1)C(=O)NCC#N
TargetCysteine Protease
SolubilityDMSO:42mg/ml

Bioactivity

In Vivo
Animal model: Rhesus monkey (15 years) receiving oophorectomy (OVX). Dosage: 0.6, 3, 15 mg/kg. Administration: P. o once daily for 8-11 days. Result: Decreased uNTx/Cre by an average of 76%, 68%, and 31% at the dose of 15, 3, and 0.6 mg/kg, respectively.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • L-006235 [orb1306274]

    98.38% (May vary between batches)

    294623-49-7

    466.6

    C24H30N6O2S

    1 ml x 10 mM (in DMSO), 200 mg, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
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Protocol Information

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2 mg
$ 110.00
5 mg
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10 mg
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25 mg
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50 mg
$ 870.00
100 mg
$ 1,240.00
500 mg
$ 2,530.00