L-Cysteinesulfinic acid monohydrate

SKU: orb1303120

Description

L-Cysteinesulfinic acid monohydrate is a potent agonist for multiple rat metabotropic glutamate receptor subtypes, including mGluR1, mGluR5, and mGluR8. This compound is a valuable research tool for investigating glutamatergic signaling in both in vitro and in vivo neurological studies.

Research Area

Metabolism Research, Neuroscience

Images & Validation

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Key Properties

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CAS Number	207121-48-0
MW	171.17
Purity	≥98%
Formula	C₃H₉NO₅S
SMILES	O.N[C@@H](CS(O)=O)C(O)=O
Target	GluR,Endogenous Metabolite
Solubility	H2O:120 mg/mL (701.06 mM)

Bioactivity

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Target IC50

In Vitro

L-Cysteinesulfinic acid (monohydrate) serves as an innate activator for the phospholipase D (PLD)-linked metabotropic excitatory amino acids (EAA) receptor, selectively triggering the PLD-associated mechanism. When applied to hippocampal slices, 1 mM concentrations of L-CSA (monohydrate) significantly enhance PLD activity, unlike similar doses of L-glutamate, L-aspartate, and L-HCA, which show no effect. Furthermore, L-CSA (monohydrate) prompts a dose-responsive elevation in PLD activity in these slices, even when iGluR antagonists are present, with the potency around an EC50 of 500 uM. Notably, the response to 1 mM L-CSA (monohydrate) in augmenting PLD activity remains unaltered by 1 uM tetrodotoxin, indicating that the effect is not reliant on an increase in neuronal activity.

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, L Cysteinesulfinic acid monohydrate, mGluR, Metabotropic glutamate receptors, Inhibitor, L-Cysteinesulfinic acid, LCysteinesulfinic acid monohydrate, L-Cysteinesulfinic acid Monohydrate

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Compound Identifiers

PubChem CID

16211766 ↗

Key Properties

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No computed properties available.

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