L-Thyroxine sodium

SKU: orb1305981

Description

L-Thyroxine sodium is the primary synthetic form of the thyroid hormone and acts as an agonist for thyroid hormone receptors alpha and beta. It is widely used in research to study metabolism, development, and gene regulation in both cellular (in vitro) and animal (in vivo) models.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	55-03-8
MW	798.85
Purity	98.74% (May vary between batches)
Formula	C₁₅H₁₀I₄NO₄.Na
SMILES	[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O
Target	Endogenous Metabolite,Thyroid hormone receptor(THR)
Solubility	DMSO:27.5 mg/mL (34.42 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.5 mM)

Bioactivity

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In Vitro	evothyroxine (L-T(4))can upregulate the expression of P-gp mRNA and protein in LS180 cells, but only L-T(4) and L-T(3) can produce the same effect in Caco-2 cells, which are relatively lacking in PXR
Cell Research	Cell lines: LS180V cells. Concentrations: 100 nM and 100μM. Incubation Time: 72 h. Method: LS180V cells are induced for 72 h with two l-T4 concentrations of 100 nM and 100 μM.
Animal Research	Animal Models: SD rats. Dosages: 20 μg/kg/day and 100 μg/kg/day. Administration: i.p.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Inhibitor, Levothyroxine, Levothyroxine sodium, inhibit, L Thyroxine sodium, L-Thyroxine, LThyroxine sodium, L-Thyroxine sodium, LT4 sodium, L-T4 sodium, T 4, T-4, Thyroid hormone receptor(THR), Thyroidhormonereceptor, Thyroidhormonereceptor(THR), Thyroid Hormone, Thyroid hormone receptor, Thyroid Hormone Receptor, THR

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Compound Identifiers

PubChem CID

23666112 ↗

Key Properties

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No computed properties available.

Protocol Information

Find More Protocols

Purity:	98.96% (May vary between batches)
CAS Number:	25416-65-3
MW:	0
Formula:	C₁₅H₁₂I₄NNaO₅

CAS Number:	6106-07-6
MW:	888.93
Formula:	C₁₅H₂₀I₄NNaO₉

Purity:	>98% (HPLC)
CAS Number:	6106-07-6
MW:	888.93
Formula:	C₁₅H₂₀I₄NNaO₉

Purity:	>98% (HPLC)
CAS Number:	55-03-8
MW:	798.85
Formula:	C₁₅H₁₀I₄NO₄.Na

L-Thyroxine sodium

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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