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L002

SKU: orb1309500

Description

L002 is a potent, cell-permeable, and reversible inhibitor of the p300 acetyltransferase (KAT3B), competitively binding its acetyl-CoA pocket with an IC50 of 1.98 µM. It blocks histone and p53 acetylation and STAT3 activation, showing research utility in studying cardiac hypertrophy and fibrosis in both cellular and animal models.

Research Area

Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

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L002

Key Properties

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CAS Number321695-57-2
MW321.35
Purity98.59% (May vary between batches)
FormulaC15H15NO5S
SMILESCOc1ccc(cc1)S(=O)(=O)ON=C1C=C(C)C(=O)C(C)=C1
TargetSTAT,Histone Acetyltransferase,Epigenetic Reader Domain
SolubilityDMSO:60 mg/mL (186.71 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.22 mM)

Bioactivity

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Target IC50
GCN5:34 µM |KAT3B:1.98 uM |PCAF:35 µM
In Vivo
L002 reverses hypertension‐induced cardiac hypertrophy and fibrosis by treatment of mice after inducing hypertension for two weeks significantly.It also reduces the levels of perivascular and interstitial collagen in the myocardium compared to non-treated hypertensive mice.
In Vitro
L002 also has weak inhibitory effects against PCAF and GCN5 (IC50s =35 and 34 μM, respectively) and is specific for p300 over a panel of deacetylases, additional acetyltransferases, and methyltransferases.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Histone Acetyltransferase, histone, HistoneAcetyltransferase, Inhibitor, GCN5, HAT, HATs, fibrosis, PCAF, inhibit, KAT3B, L 002, L002, L-002, cardiac, acetylation, p300, STAT

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
2221149 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 130.00
25 mg
$ 220.00
50 mg
$ 390.00
100 mg
$ 610.00
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