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L755507

SKU: orb1300389

Description

L755507 is a potent and selective β3-adrenergic receptor agonist with an IC50 of 35 nM. It serves as a valuable research tool for studying metabolic diseases, including in vitro receptor signaling and in vivo models of obesity and diabetes.

Research Area

Molecular Biology, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number159182-43-1
MW584.73
Purity99.88%
FormulaC30H40N4O6S
SMILESCCCCCCNC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1
TargetCRISPR/Cas9,Adrenergic Receptor
SolubilityEthanol:58.5 mg/mL (100.05 mM);DMSO:40 mg/mL (68.41 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.42 mM)

Bioactivity

Target IC50
β3-adrenoceptor:35 nM
In Vivo
Acute exposure of rhesus monkeys to L-755,507 elicits lipolysis and metabolic rate elevation, and that chronic exposure increases uncoupling protein 1 expression in rhesus brown adipose tissue.
In Vitro
L-755,507 displays an excellent activity profile as an extremely potent human β3 adrenergic receptor agonist (β3 EC50 0.43 nM), with >440-fold selectivity over β1 and β2 binding. L755507 causes a robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors(pEC50 values of 12.3). In a recent study employing a high-throughput screen to identify chemicals capable of modulating HR-mediated genome editing, L-755507 is identified that could enhance HR repair by up to ninefold.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CRISPR, CRISPR/Cas9, Beta Receptor, AdrenergicReceptor, Adrenergic Receptor, Cas9, L755507, L-755507, HDR, Inhibitor, L 755507, inhibit, β3-adrenergic receptor, β3-AR

Similar Products

  • L755507 [orb1223268]

    >98% (HPLC)

    159182-43-1

    584.7

    C30H40N4O6S

    1 g, 500 mg, 200 mg, 5 mg, 10 mg, 100 mg, 25 mg, 50 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

L755507 (orb1300389)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
¥ 1,170.00
5 mg
¥ 1,950.00
1 ml x 10 mM (in DMSO)
¥ 2,470.00
10 mg
¥ 2,860.00
25 mg
¥ 4,680.00
50 mg
¥ 6,630.00
100 mg
¥ 9,360.00
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