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LCS-1

SKU: orb2664829

Description

LCS-1 is a pyridazinone-based, selective SOD1 inhibitor. It exhibits trypanocidal activity at high doses and induces ROS-dependent cell death in glioma models, leading to the degradation of PARP and BRCA1. This compound is a useful research tool for studying oxidative stress mechanisms in cancer and parasitic diseases.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number41931-13-9
MW255.1
Purity99.28%
FormulaC11H8Cl2N2O
SMILESO=C1C(Cl)=C(Cl)C=NN1C2=CC=CC(=C2)C
TargetApoptosis
Solubility10% DMSO+90% Corn Oil:2 mg/mL (7.84 mM);DMSO:40 mg/mL (156.8 mM)

Bioactivity

Target IC50
ANBL6-WT (bortezomib-sensitive) cells:2.5 μM|ANBL6-BR (bortezomib-resistant) cells:4.6 μM|normal human bronchial epithelial cells:2.66 μM|SOD1:1.07 μM
In Vivo
In vivo experiments, LCS-1 (20 mg/kg, intraperitoneal injection every other day for 14 days) significantly inhibited the growth of multiple myeloma and prolonged the survival of MM.1S-carrying mice.
In Vitro
LCS-1 (1-10,000 nM, 24 hours) exhibits selective cytotoxicity in HCT116 cells against cells with the BLM gene and BLM-deficient cells. LCS-1 exhibited inhibitory effects on adenocarcinoma cell lines (e.g., H23, H2347, HCC827, median IC50 of 0.20 μM), whereas the IC50 for normal human bronchial epithelial cells (NHBE) was 2.66 μM. In multiple myeloma (MM) cells, LCS-1 (0, 1.25, 2 μM, 4 h) significantly inhibited SOD1 enzyme activity in a concentration-dependent manner, and LCS-1 (0, 1.25, 2.5, 5 μM, 48 h) dose-dependently reduced the survival of several MM cell lines, including MM.1R (dexamethasone-resistant), Dox40 (adriamycin-resistant), and LR5 (melphalan-resistant) cell lines. In ANBL6-WT (bortezomib-sensitive) and ANBL6-BR (bortezomib-resistant) cells, the IC50 of LCS-1 treatment for 48 hours was 2.5 μM and 4.6 μM, respectively.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

LCS1
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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LCS-1 (orb2664829)

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% DMSO +
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% Tween 80 +
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Available Sizes

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5 mg
¥ 1,040.00
1 ml x 10 mM (in DMSO)
¥ 1,170.00
10 mg
¥ 1,560.00
25 mg
¥ 2,340.00
50 mg
¥ 3,120.00
100 mg
¥ 4,290.00
200 mg
¥ 6,110.00
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