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LCS-1

SKU: orb2664829

Description

LCS-1 is a pyridazinone-based, selective SOD1 inhibitor. It exhibits trypanocidal activity at high doses and induces ROS-dependent cell death in glioma models, leading to the degradation of PARP and BRCA1. This compound is a useful research tool for studying oxidative stress mechanisms in cancer and parasitic diseases.

Research Area

Cell Biology

Images & Validation

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LCS-1

Key Properties

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CAS Number41931-13-9
MW255.1
Purity99.28% (May vary between batches)
FormulaC11H8Cl2N2O
SMILESO=C1C(Cl)=C(Cl)C=NN1C2=CC=CC(=C2)C
TargetApoptosis
Solubility10% DMSO+90% Corn Oil:2 mg/mL (7.84 mM);DMSO:40 mg/mL (156.8 mM)

Bioactivity

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Target IC50
ANBL6-WT (bortezomib-sensitive) cells:2.5 μM|ANBL6-BR (bortezomib-resistant) cells:4.6 μM|normal human bronchial epithelial cells:2.66 μM|SOD1:1.07 μM
In Vivo
In vivo experiments, LCS-1 (20 mg/kg, intraperitoneal injection every other day for 14 days) significantly inhibited the growth of multiple myeloma and prolonged the survival of MM.1S-carrying mice.
In Vitro
LCS-1 (1-10,000 nM, 24 hours) exhibits selective cytotoxicity in HCT116 cells against cells with the BLM gene and BLM-deficient cells. LCS-1 exhibited inhibitory effects on adenocarcinoma cell lines (e.g., H23, H2347, HCC827, median IC50 of 0.20 μM), whereas the IC50 for normal human bronchial epithelial cells (NHBE) was 2.66 μM. In multiple myeloma (MM) cells, LCS-1 (0, 1.25, 2 μM, 4 h) significantly inhibited SOD1 enzyme activity in a concentration-dependent manner, and LCS-1 (0, 1.25, 2.5, 5 μM, 48 h) dose-dependently reduced the survival of several MM cell lines, including MM.1R (dexamethasone-resistant), Dox40 (adriamycin-resistant), and LR5 (melphalan-resistant) cell lines. In ANBL6-WT (bortezomib-sensitive) and ANBL6-BR (bortezomib-resistant) cells, the IC50 of LCS-1 treatment for 48 hours was 2.5 μM and 4.6 μM, respectively.

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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LCS1
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Compound Identifiers

PubChem CID
779573 ↗

Key Properties

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No computed properties available.

Protocol Information

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Available Sizes

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5 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 90.00
10 mg
$ 120.00
25 mg
$ 180.00
50 mg
$ 240.00
100 mg
$ 330.00
200 mg
$ 470.00
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