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Lesopitron HCl

SKU: orb1745253

Description

Lesopitron HCl is a selective 5-HT1A receptor agonist used in neuroscience research. It exhibits anxiolytic properties and has been shown in preclinical in vivo studies to counteract the dark avoidance behavior observed during cocaine withdrawal in murine models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number132449-88-8
MW357.28
Purity99.89%
FormulaC15H22Cl2N6
SMILESCl.ClC=1C=NN(C1)CCCCN2CCN(C3=NC=CC=N3)CC2
Target5-HT Receptor
SolubilityDMSO:4.8 mg/mL (13.43 mM)

Bioactivity

In Vivo
E4424 (acute oral) increased adherent mucus levels by 12%, 11%, and 13%, relative to controls. Chronic E4424 significantly increased gastric mucus relative to controls (69% increase). E4424 has potent anti-gastric secretory and antiulcer effects.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Lesopitron HCl, Lesopitron HCl(132449-89-9 Free base), 5HT Receptor, 5HTReceptor, 5-HT1A
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Lesopitron HCl (orb1745253)

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1 mg
¥ 9,620.00
5 mg
¥ 23,920.00
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